I have a few different regions and a different market factor for each of them.

Lets say:

Europe = 0.75 of the base price list  

South America = 0.50 of the base price list.

So, I could have a different price list for each region, but this would not affect block pricing. 

First question, does anybody see a solution for this block price scenario?

The next thing I thought was to use a price rule, that based on the quote region would insert a different regular price (block price is already taken into consideration here). The problem (and question) here is, can/if I use the same field (regular price) as my source and my targeted field? Is this going to create a loop?

I am open to other ideas as well. Have any of you implemented something like this before? I imagine Salesforce CPQ addresses this kind of scenario.